Alloreactive T cells discriminate among a diverse set of endogenous peptides.

Division rate and phenotypic differences discriminate alloreactive and nonalloreactive T cells transferred in lethally irradiated mice.

After non-T-cell-depleted allogeneic hematopoietic stem cell transplantation (HSCT), both alloreactive and homeostatic signals drive proliferation of donor T cells. Host-reactive donor T cells, which proliferate on alloantigen stimulation, are responsible for the life-threatening graft-versus-host disease. Non-host-reactive donor T cells, which proliferate in response to homeostatic signals, co...

Myeloma-Induced Alloreactive T Cells

Alloreactive Memory T Cells Are Responsible

Prediction of melting points of a diverse chemical set using fuzzy regression tree

The classification and regression trees (CART) possess the advantage of being able to handlelarge data sets and yield readily interpretable models. In spite to these advantages, they are alsorecognized as highly unstable classifiers with respect to minor perturbations in the training data.In the other words methods present high variance. Fuzzy logic brings in an improvement in theseaspects due ...

Creation of H-2 class I epitopes using synthetic peptides: recognition by alloreactive cytotoxic T lymphocytes.

A major role that cytotoxic T lymphocytes (CTLs) play in the immune response is the specific destruction of viral-infected cells and tissue from foreign grafts. Class I molecules encoded within the major histocompatibility complex are the target structures for these CTLs. Recently, viral-restricted CTLs have been shown to recognize viral peptides in association with class I molecules, while sev...